Since installing a few updates at the end of June, we ran into a problem with a couple IIS servers. Because there's a lot of information on these issues I wanted to add this to the search results as a recent fix for the troubles.
When you Browse to the IIS server, you may end up with the following, though the TL;DR are:
The webpage throws a Runtime or Compile error and Event ID 1310:
Exception message: (0): error CS0016: Could not write to output file 'c:\Windows\Microsoft.NET\Framework64\v4.0.30319\Temporary ASP.NET Files\rdweb_pages\decbd09c\9f1642a3\App_Web_default.aspx.cdcab7d2.j7qh1wlj.dll' -- 'Access is denied. '